TNF-α and IL-1β but not IL-18 counteract TGF-β1 mediated stimulation of collagen accumulation and increased extracellular matrix strength and stiffness
Katerina St. Angelo, Arlen Brickman, Jeffrey R. Morgan · 2026
Read TNF-α and IL-1β but not IL-18 counteract TGF-β1 mediated stimulation of collagen accumulation and increased extracellular matrix strength and stiffness by Katerina St. Angelo, Arlen Brickman, Jeffrey R. Morgan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13324134.txt.
Description
Katerina St Angelo, Arlen Brickman, and Jeffrey Morgan wrote a 2026 paper on scarring at the level of lab-grown tissue. In fibrosis, the body lays down too much collagen, stiffening organs. A growth factor called TGF-β1 drives that buildup. The team asked whether three inflammation signals push back against it.
They grew ring-shaped tissues from human fibroblasts in molds, letting the cells build their own collagen web. After one and two weeks they measured collagen, strength, and stiffness. Two of the signals cut collagen and weakened the tissue, and they canceled the growth factor's boost. The third had little effect. The contrast helps explain why inflammation and scarring do not simply rise together.
Catalog record
| CREATOR | Katerina St. Angelo, Arlen Brickman, Jeffrey R. Morgan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |