Identification of Centrosome Duplication‐Related Biomarkers in Hypertrophic Cardiomyopathy Through Integrative Multi‐Omics, Single‐Cell Transcriptomics, and Experimental Validation
Huigan Li, Weihua Liu, Xun Huang, Zhigang You, Lin Huang · 2026
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Description
Huigan Li and team hunted for biomarkers of hypertrophic cardiomyopathy among genes tied to centrosome duplication. Their 2026 study combined differential expression analysis, co-expression networks, Mendelian randomization, and several machine learning models, then checked cell-type patterns with single-cell RNA sequencing and functional assays in cardiomyocytes. Hypertrophic cardiomyopathy thickens the ventricular wall and scars heart muscle, yet the role of centrosome-related genes in it had stayed unclear.
Two candidates emerged, HBEGF and VPS8, with VPS8 standing out as a key regulator linking endosomal and lysosomal balance to immune-related remodeling. The authors propose VPS8 as both a candidate biomarker for early diagnosis and a potential therapeutic target, with HBEGF as a second lead. Because the findings rest on computational finding plus laboratory validation, they frame the next step as testing whether these markers hold up in patients and point to treatments.
Catalog record
| CREATOR | Huigan Li, Weihua Liu, Xun Huang, Zhigang You, Lin Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |