Tibial transverse transport promotes diabetic foot ulcer healing by regulating miR-182-5p
Tongliang Xie, Haojie Li, Zuyan Sun, Rui Li, Wenliang Huang · 2026
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Description
Tongliang Xie and co-authors show how a bone transport technique heals diabetic foot ulcers through a microRNA, in this 2026 Europe PMC paper. Tibial transverse transport, a mechanical procedure, is known to help these stubborn wounds, but its molecular route was unclear. The team modeled the ulcers in diabetic rabbits and profiled wound tissue genes.
The procedure reshaped the microRNA profile of granulation tissue, with one candidate, miR-182-5p, rising most. Boosting that microRNA in skin fibroblasts grown in high sugar restored their growth and movement and raised activity in a pathway driving blood vessel growth signals. Two other microRNAs also rose and may assist repair through their own pathways.
Catalog record
| CREATOR | Tongliang Xie, Haojie Li, Zuyan Sun, Rui Li, Wenliang Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |