Ex situ heart perfusion: a novel model for drug validation and translation
John Onsy Louca, Magnus Althage, Nicole Asemota, Johannes Bargehr, Sai Bhagra, Dawn E. Bowles, Sarah Hosgood, Kiran Khush, Simon Messer, Marco Öchsner, Joao Pedro Nunes, Amanda Rodgers, Lu Wang, Catherine H. Wilson, Stephen Large, Sanjay Sinha · 2026
Read Ex situ heart perfusion: a novel model for drug validation and translation by John Onsy Louca, Magnus Althage, Nicole Asemota, Johannes Bargehr, Sai Bhagra, Dawn E. Bowles, Sarah Hosgood, Kiran Khush, Simon Messer, Marco Öchsner, Joao Pedro Nunes, Amanda Rodgers, Lu Wang, Catherine H. Wilson, Stephen Large, Sanjay Sinha (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13323499.txt.
Description
John Onsy Louca leads a large team arguing that perfused donor hearts should serve as a first testing ground for new drugs, in a 2026 perspective. Keeping hearts beating outside the body, a method rooted in Langendorff's nineteenth-century work, now underpins donation programmes after circulatory death.
The proposal uses hearts turned down for transplant, plus hearts removed from transplant recipients, for first-in-human studies with minimal patient risk. Weak drugs could then be dropped long before costly mid and late stage trials, where lack of effect sinks many candidates. Longer perfusion times are the key technical need, and the authors call for joint work among industry, universities and clinicians to spread the model.
Catalog record
| CREATOR | John Onsy Louca, Magnus Althage, Nicole Asemota, Johannes Bargehr, Sai Bhagra, Dawn E. Bowles, Sarah Hosgood, Kiran Khush, Simon Messer, Marco Öchsner, Joao Pedro Nunes, Amanda Rodgers, Lu Wang, Catherine H. Wilson, Stephen Large, Sanjay Sinha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43164 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |