Astrocyte-derived miR-124 impairs glioma cell volume regulation and migration by reducing Ca2+-dependent IK channel expression and activation
Myriam Catalano, Arianna Rinaldi, Angela Di Battista, Cristina Limatola, Luigi Catacuzzeno, Antonio Michelucci · 2026
Read Astrocyte-derived miR-124 impairs glioma cell volume regulation and migration by reducing Ca2+-dependent IK channel expression and activation by Myriam Catalano, Arianna Rinaldi, Angela Di Battista, Cristina Limatola, Luigi Catacuzzeno, Antonio Michelucci (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13323428.txt.
Description
Myriam Catalano and co-authors published a 2026 study of how astrocytes, the star-shaped cells of the brain, restrain glioma tumor cells through a tiny RNA strand they pass on, miR-124. Astrocytes help set the volume of such tumor cells. Volume determines how well the cells can invade. The strand travels in small packages that the astrocytes shed, called vesicles.
Here the team names a new target hit by the strand: a channel that lets potassium out of the cell, switched on by calcium inside the cell fluid. The strand reduces two gates that release calcium from the internal store of the cell. With less calcium released, a signaling pathway dims, and the gene for the channel is read less. Activation of the channel, driven by calcium from the store, fell sharply in the presence of the strand. Tumor cells in three dimensions moved less.
Catalog record
| CREATOR | Myriam Catalano, Arianna Rinaldi, Angela Di Battista, Cristina Limatola, Luigi Catacuzzeno, Antonio Michelucci |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |