Circulating IL-33 as a sensitive alarmin in systemic lupus erythematosus: a biomarker for disease activity and skin-specific manifestations
Li Li, Xi Tan, Chen Zhao, Sijian Wen, Wenyu Li, Runge Fan, Wei Hou, Youkun Lin · 2026
Read Circulating IL-33 as a sensitive alarmin in systemic lupus erythematosus: a biomarker for disease activity and skin-specific manifestations by Li Li, Xi Tan, Chen Zhao, Sijian Wen, Wenyu Li, Runge Fan, Wei Hou, Youkun Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13323393.txt.
Description
Lupus can flare in the skin as well as the joints and organs, and Li Li and co-authors asked whether a blood signal called interleukin-33 tracks that activity. They compared 133 patients with the disease against 81 healthy controls, measuring the signal in plasma and relating it to disease scores, sun sensitivity, and where skin lesions appeared. Skin tissue samples added a check on where the signal's receptor sits.
Patients carried far higher levels than controls, and higher levels went with worse disease scores and with facial lesions and sun sensitivity. The receptor was denser in face and head skin than elsewhere on the body. Levels also ran higher in men and in patients not yet treated. The authors propose the signal as a marker for sorting patients into groups.
Catalog record
| CREATOR | Li Li, Xi Tan, Chen Zhao, Sijian Wen, Wenyu Li, Runge Fan, Wei Hou, Youkun Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |