Gone but Not Forgotten: Toward an Integrated Strategy for the Left Atrial Appendage in Atrial Fibrillation
Robert N. D'Angelo, Natalia C. Berry · 2026
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Description
Robert N D'Angelo and Natalia C Berry argue in a 2026 commentary that care for the left atrial appendage in atrial fibrillation needs one joined strategy. The appendage triggers rhythm trouble and supplies most clots in this disease, so isolating it electrically and closing it mechanically are often discussed apart.
Trials pull in mixed directions: isolation cut recurrence in the BELIEF trial, device closure matched drug care in OPTION and CHAMPION-AF, yet CLOSURE-AF missed its target in older, higher-risk patients. Stroke risk after isolation, from weak appendage contraction, pushes many clinicians toward closure anyway. The authors weigh why results differ, including leftover patency, and propose treating isolation and closure as one planned package.
Catalog record
| CREATOR | Robert N. D'Angelo, Natalia C. Berry |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7325 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |