Mutation profile and therapeutic implications in Peutz-Jeghers syndrome-associated gastric-type endocervical adenocarcinoma
Tianhui Niu, Xiaofang Liu, Siqi Zhang, Mengnan Yu, Xiaoying Wang, Jinghui Jia · 2026
Read Mutation profile and therapeutic implications in Peutz-Jeghers syndrome-associated gastric-type endocervical adenocarcinoma by Tianhui Niu, Xiaofang Liu, Siqi Zhang, Mengnan Yu, Xiaoying Wang, Jinghui Jia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13323026.txt.
Description
Tianhui Niu and co-authors profile gene changes in a rare cervical cancer tied to Peutz-Jeghers syndrome, in a 2026 single-patient study. Gastric-type endocervical adenocarcinoma is aggressive and unrelated to HPV, and its appearance in this inherited syndrome is exceptionally rare.
Targeted sequencing and tissue staining covered one well-described patient with stage IB3 disease. Testing found an inherited STK11 change plus tumour changes in KRAS and ERBB3, and strong staining for Claudin18.2 and MUC6 confirmed the gastric character, while p16 stayed negative. Claudin18.2 gives a proven target from gastric cancer care, and ERBB signals offer another lead. The authors propose routine molecular profiling for this cancer type.
Catalog record
| CREATOR | Tianhui Niu, Xiaofang Liu, Siqi Zhang, Mengnan Yu, Xiaoying Wang, Jinghui Jia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22174 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |