Targeting liver metastases in uveal melanoma: ATX-LPA mediated immunosuppression and novel therapeutic approaches
Jacqueline A. Turner, Marc D’Antonio, Heather N. Montane, Morgan MacBeth, Elizabeth Katsnelson, William A. Robinson, Richard P. Tobin, Kasey L. Couts, Svetomir N. Markovic, Raul M. Torres · 2026
Read Targeting liver metastases in uveal melanoma: ATX-LPA mediated immunosuppression and novel therapeutic approaches by Jacqueline A. Turner, Marc D’Antonio, Heather N. Montane, Morgan MacBeth, Elizabeth Katsnelson, William A. Robinson, Richard P. Tobin, Kasey L. Couts, Svetomir N. Markovic, Raul M. Torres (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322911.txt.
Description
Jacqueline A. Turner leads a study of liver spread in uveal melanoma, published in 2026, centred on a lipid signal that quiets immune attack. Eye melanoma spreads to the liver with striking frequency, where local immune tolerance helps tumours resist immune therapy.
The team measured autotaxin, the enzyme that makes lysophosphatidic acid, in liver resident cells and in killer T cells taken from liver tumours, blood and healthy donors. Autotaxin was present on Kupffer cells and linked to suppressive markers, and the signal altered how antigen-specific T cells behaved under long exposure. Mouse cells lacking the LPA receptor 5 helped pin down the path. Liver-directed treatment outcomes are reviewed alongside these findings.
Catalog record
| CREATOR | Jacqueline A. Turner, Marc D’Antonio, Heather N. Montane, Morgan MacBeth, Elizabeth Katsnelson, William A. Robinson, Richard P. Tobin, Kasey L. Couts, Svetomir N. Markovic, Raul M. Torres |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42601 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |