Metrnl and macrophage polarization: role in skeletal muscle homeostasis and therapeutic potential
Bo Huang, Haihua Xie, Weilu Li, Yimin Chen, Panpan Mu, Lingshan Yu, Yuebing Li, Xuqiu Zeng, Jiadong Zang, Liang Peng · 2026
Read Metrnl and macrophage polarization: role in skeletal muscle homeostasis and therapeutic potential by Bo Huang, Haihua Xie, Weilu Li, Yimin Chen, Panpan Mu, Lingshan Yu, Yuebing Li, Xuqiu Zeng, Jiadong Zang, Liang Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322843.txt.
Description
Bo Huang and a large team review how the muscle signal protein Metrnl shapes immune cells in skeletal muscle, in a 2026 article. Macrophages in muscle can shift form and thereby affect repair, metabolism and the local immune setting.
Metrnl, a protein released by muscle, acts through a linked set of signals to steer that shift, with effects on sugar control and age-related muscle loss seen in human and rodent studies. Its action runs both ways and depends heavily on tissue and disease, so results in one setting may not transfer to another. Open questions include where its receptor sits and how it affects each macrophage type, with gene-wide and imaging tools proposed for next steps.
Catalog record
| CREATOR | Bo Huang, Haihua Xie, Weilu Li, Yimin Chen, Panpan Mu, Lingshan Yu, Yuebing Li, Xuqiu Zeng, Jiadong Zang, Liang Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49713 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |