Higher-order brain processes, rather than early processing, underlie sensory problems in ME/CFS: evidence from ERPs

Sanjay Kumar, Alfred Veldhuis, Farzaneh Yazdani · 2026

Read Higher-order brain processes, rather than early processing, underlie sensory problems in ME/CFS: evidence from ERPs by Sanjay Kumar, Alfred Veldhuis, Farzaneh Yazdani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322831.txt.

Description

Sanjay Kumar, Alfred Veldhuis and Farzaneh Yazdani test where sensory problems in ME/CFS arise in the brain, in a 2026 study using event-related potentials. Their group included 31 people with ME/CFS and 30 healthy matched controls.

Patients reported far more sensory problems than controls in daily life. On a paired-click task, early brain filtering, measured by P50 suppression, did not differ between groups. On an oddball task, the later P300 response was clearly smaller in patients, pointing to higher-order control systems rather than early sensing. The authors argue that help for sensory trouble in ME/CFS should target those later brain systems, not the senses themselves.

Catalog record

CREATORSanjay Kumar, Alfred Veldhuis, Farzaneh Yazdani
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE33620
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13322831

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