Mechanisms of vascular calcification: cellular phenotype switching drives matrix remodeling and mineralized microenvironment formation
Haoyu Wen, Weiwei Chen, Yuquan He · 2026
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Description
Haoyu Wen, Weiwei Chen and Yuquan He explain how blood vessel walls harden with calcium, in a 2026 review of vascular calcification. The process is now seen as active, driven by smooth muscle cells in the vessel wall rather than simple mineral build-up.
Under strain from calcium and phosphate imbalance, sugar and fat toxicity, oxidative stress and long-term inflammation, those cells switch toward a bone-like state. They release tiny vesicles, break down surrounding matrix and switch on growth signals such as Wnt and BMP pathways. Other cell changes add to the effect. The authors discuss treatment ideas that target metabolic control points, block the cell switch, or alter gene regulation.
Catalog record
| CREATOR | Haoyu Wen, Weiwei Chen, Yuquan He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93512 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |