Choline supplementation protects against sepsis-induced lung injury, potentially through suppression of Prtn3-associated monocyte activation
Li-Ming Xu, Wei-Can Chen, Zhen-Dong Sun, Li-Hong Zhang, Yi-Bin Liu, Xiao-Ting Luo, Yan Chen, Lin Lin, He-Fan He · 2026
Read Choline supplementation protects against sepsis-induced lung injury, potentially through suppression of Prtn3-associated monocyte activation by Li-Ming Xu, Wei-Can Chen, Zhen-Dong Sun, Li-Hong Zhang, Yi-Bin Liu, Xiao-Ting Luo, Yan Chen, Lin Lin, He-Fan He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322800.txt.
Description
Li-Ming Xu and co-authors test choline supplements against sepsis lung injury in mice in a 2026 study. Sepsis can flood and scar the lungs, and choline is known to shape inflammation and immune responses. Lung injury was induced by a standard gut puncture method, and blood choline plus lung harm were measured with and without supplements.
Injured mice had lower blood choline than healthy controls. Supplements eased lung bleeding, swelling, wall thickening, and injury scores, and lowered inflammatory signals. Combined gene and protein scans flagged a target gene, Prtn3, concentrated in monocyte type immune cells. In cell tests, choline calmed inflammatory responses, and forcing Prtn3 back up partly undid that calm.
Catalog record
| CREATOR | Li-Ming Xu, Wei-Can Chen, Zhen-Dong Sun, Li-Hong Zhang, Yi-Bin Liu, Xiao-Ting Luo, Yan Chen, Lin Lin, He-Fan He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50360 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |