Refining drug screening with automated home cage monitoring: a crossover study in socially housed rats
David A. Connor, Brady Nifong, Jason D. Payseur, XueJun Wu, Eric I. Rossman, Ajeesh Koshy Cherian · 2026
Read Refining drug screening with automated home cage monitoring: a crossover study in socially housed rats by David A. Connor, Brady Nifong, Jason D. Payseur, XueJun Wu, Eric I. Rossman, Ajeesh Koshy Cherian (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322677.txt.
Description
David A. Connor and co-authors validate automated home cage monitoring for early drug safety checks in a 2026 rat study. Brain related side effects sink many drug candidates, and the standard observation battery relies on brief, subjective human scoring. An automated Home Cage Analyzer watches rats in their own cages around the clock.
In a crossover design where each rat served as its own control, three known drugs were tested: amphetamine, diazepam, and chlorpromazine. The system caught expected stimulant and sedative effects across light and dark phases. At the top amphetamine dose, floor movement fell while rearing rose sharply, a nuance brief checks could miss. The team backs the tool as a first line screen.
Catalog record
| CREATOR | David A. Connor, Brady Nifong, Jason D. Payseur, XueJun Wu, Eric I. Rossman, Ajeesh Koshy Cherian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45640 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |