Modulating α-synuclein clearance: a comparison of high-frequency and direct current stimulation in preclinical models of Parkinson's disease
Minesh Kapadia, Lorraine V Kalia, Suneil K Kalia · 2026
Read Modulating α-synuclein clearance: a comparison of high-frequency and direct current stimulation in preclinical models of Parkinson's disease by Minesh Kapadia, Lorraine V Kalia, Suneil K Kalia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322620.txt.
Description
Minesh Kapadia, Lorraine V Kalia, and Suneil K Kalia write a 2026 letter on electrical stimulation and protein clearance in Parkinson's disease. The disease kills dopamine neurons as a protein, alpha-synuclein, misfolds into toxic clumps and Lewy bodies. Current drugs and standard brain stimulation ease symptoms but do not slow neuron loss, so boosting clump clearance is a live research goal.
The letter discusses a study by Bechkos and others where direct current stimulation cut clump build-up in cultured neurons and improved cell survival. The writers note that this matches and extends their own group's finding that high frequency stimulation aids clearance. Comparing stimulation styles may shape future disease slowing therapy.
Catalog record
| CREATOR | Minesh Kapadia, Lorraine V Kalia, Suneil K Kalia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10880 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |