Structural variants are enriched in deleterious visible phenotypes in Drosophila
Alejandra Samano, Matthew Musat, Mihir Junaghare, Asad Ahmad, Mehlum Ali, Sebastian Alves, Sreeram Pasupuleti, Jelisha Perera, Omar Saada, Brady Sabido, Trevor Smi1th, Sophie Walz, Mahul Chakraborty · 2026
Read Structural variants are enriched in deleterious visible phenotypes in Drosophila by Alejandra Samano, Matthew Musat, Mihir Junaghare, Asad Ahmad, Mehlum Ali, Sebastian Alves, Sreeram Pasupuleti, Jelisha Perera, Omar Saada, Brady Sabido, Trevor Smi1th, Sophie Walz, Mahul Chakraborty (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322080.txt.
Description
Alejandra Samano and a large student team hunt the gene faults behind classic fruit fly traits in a 2026 study. Structural variants, large DNA rearrangements, form much trait variation but hide from short read sequencing. Long read assemblies for 11 Drosophila melanogaster strains were joined into a pangenome graph with fine maps of those variants.
The team traced 50 classic visible traits and found new candidate faults for 15 of them. A wing vein trait linked to a 1.5 kilobase partial gene duplication, and the century old Curved wing trait linked to a 7.5 kilobase retrotransposon breaking a muscle gene. Harmful visible traits proved rich in structural variants.
Catalog record
| CREATOR | Alejandra Samano, Matthew Musat, Mihir Junaghare, Asad Ahmad, Mehlum Ali, Sebastian Alves, Sreeram Pasupuleti, Jelisha Perera, Omar Saada, Brady Sabido, Trevor Smi1th, Sophie Walz, Mahul Chakraborty |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65360 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |