Influence of cis-regulatory elements on expression divergence in human segmental duplications
Colin J Shew, Gulhan Kaya, Sean P McGinty, Megan Y Dennis · 2026
Read Influence of cis-regulatory elements on expression divergence in human segmental duplications by Colin J Shew, Gulhan Kaya, Sean P McGinty, Megan Y Dennis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13322076.txt.
Description
Colin J Shew and co-authors study gene control switches in human specific duplicated DNA in a 2026 report. Segmental duplications hold millions of letters found only in humans, including genes shaping brain growth. Though under six million years old, duplicated genes already show wide differences in activity between copies.
Using long read data, the team found human specific copies tend to run quieter than ancestral ones. A mass reporter test of 7760 duplicated and chimpanzee matching stretches found 14 to 24 percent with differing activity, mostly by small amounts. Predicted switch activity tracked gene output in nerve cells, and checks on three genes supported copy specific expression patterns.
Catalog record
| CREATOR | Colin J Shew, Gulhan Kaya, Sean P McGinty, Megan Y Dennis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49110 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |