Iba1 deficiency impairs microglial synaptic remodeling and neuronal survival after axonal injury
Koji Sekiguchi, Hirotaka Shoji, Tomoko Shindo, Jumpei Sasabe, Daiki Tokuyasu, Jin Nakahara, Tsuyoshi Miyakawa, Daisuke Ito · 2026
Read Iba1 deficiency impairs microglial synaptic remodeling and neuronal survival after axonal injury by Koji Sekiguchi, Hirotaka Shoji, Tomoko Shindo, Jumpei Sasabe, Daiki Tokuyasu, Jin Nakahara, Tsuyoshi Miyakawa, Daisuke Ito (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13321657.txt.
Description
When a nerve is cut, the brain's guard cells wrap the hurt cell and prune its inputs, a remodel that helps it live. Koji Sekiguchi and seven co-authors show in 2026 that one guard protein, Iba1, is load-bearing in that wrap. Mice bred without it were lighter and slightly odd at rest. After a face nerve cut, their guard cells hugged the hurt cells less, and the pruning of inputs never came.
Gene reads showed the guard cells stuck in an alarm state, louder than in sound mice. A month on, fewer hurt cells lived in the bare mice, and their nuclei bore more harm marks. The team read Iba1 as the handshake between guard and neuron, without which rescue turns to noise.
Catalog record
| CREATOR | Koji Sekiguchi, Hirotaka Shoji, Tomoko Shindo, Jumpei Sasabe, Daiki Tokuyasu, Jin Nakahara, Tsuyoshi Miyakawa, Daisuke Ito |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |