Epigenetic age acceleration mediates the association between pro-inflammatory and pro-oxidant diets and the progression and mortality of cardiovascular-kidney-metabolic syndrome
Shuang Wu, Siqi Lyu, Zhenkun Yang, Tianshu Gu, Yimeng Wang, Juan Wang, Jun Zhu, Yanmin Yang, Yang Chen, Lihui Zheng · 2026
Read Epigenetic age acceleration mediates the association between pro-inflammatory and pro-oxidant diets and the progression and mortality of cardiovascular-kidney-metabolic syndrome by Shuang Wu, Siqi Lyu, Zhenkun Yang, Tianshu Gu, Yimeng Wang, Juan Wang, Jun Zhu, Yanmin Yang, Yang Chen, Lihui Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13321538.txt.
Description
Diets that inflame and oxidize may age the body faster, and Wu and co-authors test whether that speed-up links bad diets to the heart-kidney-metabolic syndrome. They mine a national survey of adults from 1999 to 2002, scoring each diet for inflammatory punch and antioxidant balance, and each person's epigenetic age drift from DNA marks. Syndrome stage and later deaths complete the picture.
Pro-inflammatory, low-antioxidant eaters stood at worse syndrome stages and died more often, while the reverse pattern protected. Two aging measures carried part of the diet effect in the mediation analysis. The authors pitch better diet quality as a lever against the syndrome's spread.
Catalog record
| CREATOR | Shuang Wu, Siqi Lyu, Zhenkun Yang, Tianshu Gu, Yimeng Wang, Juan Wang, Jun Zhu, Yanmin Yang, Yang Chen, Lihui Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |