CircPTP4A2 (hsa_circ_0007364) facilitates non-small cell lung cancer progression by regulating miR-127-5p/SMC3
Yali Feng, Jiang Hong, Changgang Yang, Chun Cheng, Yujie Xue, Jiaqi Zhang, Yu Lu, Xiang Cao, Gengxi Jiang, Xiaodan Chong · 2026
Read CircPTP4A2 (hsa_circ_0007364) facilitates non-small cell lung cancer progression by regulating miR-127-5p/SMC3 by Yali Feng, Jiang Hong, Changgang Yang, Chun Cheng, Yujie Xue, Jiaqi Zhang, Yu Lu, Xiang Cao, Gengxi Jiang, Xiaodan Chong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13321512.txt.
Description
Yali Feng and co-authors traced in 2026 how a ring-shaped RNA drives lung cancer growth through a two-step relay. The ring, circPTP4A2, was read in tumor and near tissue from fifty patients with non-small cell lung cancer. It ran high in tumors and tracked with worse survival. In two cancer cell lines, muting the ring slowed growth and spread sharply.
The relay runs through a small RNA and a chromosome-care protein, SMC3. Tuning either one undid the effects of muting the ring, which pins the chain in place. The team names the ring a promoter of this cancer and a candidate mark for spotting it early. Drug work on the chain is the stated next step.
Catalog record
| CREATOR | Yali Feng, Jiang Hong, Changgang Yang, Chun Cheng, Yujie Xue, Jiaqi Zhang, Yu Lu, Xiang Cao, Gengxi Jiang, Xiaodan Chong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |