Proof-of-concept engineering of Escherichia coli expressing a bee-derived cytochrome P450 monooxygenase for thiamethoxam detoxification
Pachara Sattayawat, Kasimaporn Promubon, Kritapas Sripinta, Warisa Chunguaongsuk, Chonlaphon Juntama, Nuttapol Noirungsee, Aussara Panya, Terd Disayathanoowat · 2026
Read Proof-of-concept engineering of Escherichia coli expressing a bee-derived cytochrome P450 monooxygenase for thiamethoxam detoxification by Pachara Sattayawat, Kasimaporn Promubon, Kritapas Sripinta, Warisa Chunguaongsuk, Chonlaphon Juntama, Nuttapol Noirungsee, Aussara Panya, Terd Disayathanoowat (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13321449.txt.
Description
Bees pick up farm pesticides by accident, and friendly gut microbes might one day help them break those poisons down. Pachara Sattayawat and co-authors built a test microbe for that idea in 2026. They placed a bee detox gene into a common lab bacterium. The gene makes an enzyme that can change a widely used insect spray called thiamethoxam.
First they checked how the spray alone harms the lab bacterium at high doses. Computer models then reshaped the enzyme so it would dissolve well in its new host. A plasmid carried the gene in, and growth settings were tuned for best output. A whole-cell test then put the microbe to work on the spray. The study is a proof of concept for microbe-aided detox in bees.
Catalog record
| CREATOR | Pachara Sattayawat, Kasimaporn Promubon, Kritapas Sripinta, Warisa Chunguaongsuk, Chonlaphon Juntama, Nuttapol Noirungsee, Aussara Panya, Terd Disayathanoowat |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |