Testing the biobehavioral regulation of negative emotion as a mechanism of change in transdiagnostic youth psychotherapy: study protocol for a randomized controlled trial

Madison Aitken, Brendan F. Andrade, Claire E. Krasinkiewicz, Sabrina W. S. Chan, Sera P. Gandhi, Jessica W. Pun, Andrew Hamilton-Wright, Wei Wang, Leah Sack, John R. Weisz, Robert Bancroft, Jo Henderson, Kristel Thomassin · 2026

Read Testing the biobehavioral regulation of negative emotion as a mechanism of change in transdiagnostic youth psychotherapy: study protocol for a randomized controlled trial by Madison Aitken, Brendan F. Andrade, Claire E. Krasinkiewicz, Sabrina W. S. Chan, Sera P. Gandhi, Jessica W. Pun, Andrew Hamilton-Wright, Wei Wang, Leah Sack, John R. Weisz, Robert Bancroft, Jo Henderson, Kristel Thomassin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13321423.txt.

Description

Madison Aitken and co-authors set out, in a 2026 protocol paper, a trial to test if calm control of ill feelings is how youth therapy works. Youth anxiety, low mood, and rule breaks are common, yet therapy helps just a fair amount. A weak grip on ill feelings cuts across all three ills, but few tests have read it as the path of change. The trial will use MATCH, a known program that mixes parts for anxiety, low mood, trauma, or conduct ills. That mix suits a test of shared paths.

Two sites will run the trial, and youth will be split by chance to therapy or a control. Body and behavior reads of ill-feeling control will track the course. The aim is proof of the path, so care can be tuned to it.

Catalog record

CREATORMadison Aitken, Brendan F. Andrade, Claire E. Krasinkiewicz, Sabrina W. S. Chan, Sera P. Gandhi, Jessica W. Pun, Andrew Hamilton-Wright, Wei Wang, Leah Sack, John R. Weisz, Robert Bancroft, Jo Henderson, Kristel Thomassin
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE60 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13321423

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