Genotype Complexity Modulates Antimalarial Susceptibility in vitro
Chinedu Ogbonnia Egwu, Olusola Ajibaye, Fatoumata Bojang, Haddijatou Mbye, Vincent Ntui Ntui-Njock, Ndey Fatou Drammeh, Eniyou Cheryll Oriero, Alfred Amambua-Ngwa · 2026
Read Genotype Complexity Modulates Antimalarial Susceptibility in vitro by Chinedu Ogbonnia Egwu, Olusola Ajibaye, Fatoumata Bojang, Haddijatou Mbye, Vincent Ntui Ntui-Njock, Ndey Fatou Drammeh, Eniyou Cheryll Oriero, Alfred Amambua-Ngwa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13321159.txt.
Description
Chinedu Ogbonnia Egwu and co-authors test how mixed malaria infections respond to drugs in a 2026 laboratory study. Rising tolerance to malaria drugs threatens progress against the disease, yet natural infections often carry several parasite strains at once. The team asked whether resistant strains in a mix drive the whole response.
Fifteen Gambian field samples plus two lab strains were exposed to standard drugs at low doses, and survival and reinvasion were measured. Resistant types shifted drug response clearly, most sharply for chloroquine in mixed cultures. Field samples with resistant markers survived more and reinvaded red cells at high rates after low dose exposure. Mixed infections thus cannot be judged by their weakest strain.
Catalog record
| CREATOR | Chinedu Ogbonnia Egwu, Olusola Ajibaye, Fatoumata Bojang, Haddijatou Mbye, Vincent Ntui Ntui-Njock, Ndey Fatou Drammeh, Eniyou Cheryll Oriero, Alfred Amambua-Ngwa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33212 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |