E3 ligase SMURF2 promotes adipogenesis and improves obesity complications by suppressing TGF-β signaling
Xueqin Wu, Muchen Wu, Shiyu Du, Jiaxin Liu, Ruiping Wang, Yuhan Sun, Zhi Zheng, Junru Yang, Xiaowei Jia, Lulu Wang, Tao Lu, Chun Yang, Yan Gao, Dongliang Fang · 2026
Read E3 ligase SMURF2 promotes adipogenesis and improves obesity complications by suppressing TGF-β signaling by Xueqin Wu, Muchen Wu, Shiyu Du, Jiaxin Liu, Ruiping Wang, Yuhan Sun, Zhi Zheng, Junru Yang, Xiaowei Jia, Lulu Wang, Tao Lu, Chun Yang, Yan Gao, Dongliang Fang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13320998.txt.
Description
Xueqin Wu and co-authors uncover a fat building helper that eases obesity's harms in this 2026 study. A growth signal pathway, TGF-beta, hampers the making of new fat cells and swells existing ones in obesity. The team hunted for what reins that pathway in during fat formation.
Early in fat cell development, the pathway's messenger proteins get tagged for disposal. The tagger is SMURF2, an enzyme that marks proteins for destruction. Cells without it formed fat poorly, while extra SMURF2 in mice spurred healthy new fat growth, resisted diet driven obesity, and improved sugar and fat handling. A peptide that shields one messenger from the tagger also helped obese mice, a twist the authors flag for therapy design.
Catalog record
| CREATOR | Xueqin Wu, Muchen Wu, Shiyu Du, Jiaxin Liu, Ruiping Wang, Yuhan Sun, Zhi Zheng, Junru Yang, Xiaowei Jia, Lulu Wang, Tao Lu, Chun Yang, Yan Gao, Dongliang Fang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |