Triptolide loaded cerium oxide nanozyme based oral nanoplatform for targeted colitis therapy
Jing Lu, Yiming Chen, Wenxing Ding, Shuhui Zheng, Liping Yang, Yiting Wang, Qingdong Ji, Chendong Qi, Feng Gao · 2026
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Description
Jing Lu and co-authors build an oral nano treatment for ulcerative colitis in a 2026 study. Colitis involves immune upset and lasting bowel swelling. Cerium oxide particles can mop up harmful oxygen molecules but lack direct calming effects, while triptolide calms swelling yet harms the gut at useful doses. The team loaded triptolide onto the particles to join both strengths.
Three natural carriers helped form tiny balls that reach the colon and release their load when bowel enzymes act. In mice with colitis, the treatment eased weight loss, colon shortening, and tissue damage. It lowered harmful oxygen and swelling signals, cut immune cell inflow, and supported the bowel mucus barrier.
Catalog record
| CREATOR | Jing Lu, Yiming Chen, Wenxing Ding, Shuhui Zheng, Liping Yang, Yiting Wang, Qingdong Ji, Chendong Qi, Feng Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64198 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |