Adverse and adaptive placental DNA methylation changes linking prenatal air pollution exposure to child lung function: findings from the SEPAGES cohort
Lucile Broséus, Valérie Siroux, Gaëlle Uzu, Anouk Marsal, Cécile Tassel, Jörg Tost, Anne Boudier, Stephan Gabet, Sofia Aguilar-Lacasaña, Frédérique White, Kyle A. Campbell, Todd M. Everson, Marie-France Hivert, Sylvain Carras, Sarah Lyon-Caen, Rémy Slama, Claire Philippat, Sam Bayat, Olivier François, Johanna Lepeule · 2026
Read Adverse and adaptive placental DNA methylation changes linking prenatal air pollution exposure to child lung function: findings from the SEPAGES cohort by Lucile Broséus, Valérie Siroux, Gaëlle Uzu, Anouk Marsal, Cécile Tassel, Jörg Tost, Anne Boudier, Stephan Gabet, Sofia Aguilar-Lacasaña, Frédérique White, Kyle A. Campbell, Todd M. Everson, Marie-France Hivert, Sylvain Carras, Sarah Lyon-Caen, Rémy Slama, Claire Philippat, Sam Bayat, Olivier François, Johanna Lepeule (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13320500.txt.
Description
Lucile Broséus and a large cohort team examine in 2026 how air pollution before birth may shape a baby's lung function. The French SEPAGES cohort supplied placenta tissue, personal pollution sensors, and lung tests at two months of age for 395 families. The team focused on chemical marks on DNA in the placenta as a possible link in the chain.
Marks at 30 single sites and 166 wider regions helped explain links between pollution and lung results. Most signals tied to the oxidising power of fine dust, rather than to dust mass alone. The work points to the placenta as a record of early exposure and a place where later breathing risk may first be set.
Catalog record
| CREATOR | Lucile Broséus, Valérie Siroux, Gaëlle Uzu, Anouk Marsal, Cécile Tassel, Jörg Tost, Anne Boudier, Stephan Gabet, Sofia Aguilar-Lacasaña, Frédérique White, Kyle A. Campbell, Todd M. Everson, Marie-France Hivert, Sylvain Carras, Sarah Lyon-Caen, Rémy Slama, Claire Philippat, Sam Bayat, Olivier François, Johanna Lepeule |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74375 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |