CC16 alleviates PM2.5-induced airway inflammation in asthmatic mice by targeting the E-cadherin-mediated ferroptosis regulatory axis
Aili Wang, Shuo Yang, Fang Xu, Jianling Liu, Jinle Lin, Jian Wu · 2026
Read CC16 alleviates PM2.5-induced airway inflammation in asthmatic mice by targeting the E-cadherin-mediated ferroptosis regulatory axis by Aili Wang, Shuo Yang, Fang Xu, Jianling Liu, Jinle Lin, Jian Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13320470.txt.
Description
Aili Wang and colleagues present a 2026 mouse and cell study on fine dust in the air and asthma. The team asked how a lung protein called CC16 guards airway cells against a type of cell death linked to iron and fat damage. Dust exposure is known to worsen asthma and harm the lining of the airways.
Tests with proteomics and cell assays pointed to E-cadherin, a protein that holds lining cells together, as a key partner for CC16. Dust lowered E-cadherin and raised cell damage, while added CC16 restored it and cut fat damage. Blocking the E-cadherin gene removed the benefit, which marks a fresh target for asthma care tied to polluted air.
Catalog record
| CREATOR | Aili Wang, Shuo Yang, Fang Xu, Jianling Liu, Jinle Lin, Jian Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46640 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |