Reprogramming the enduracidin NRPS assembly line via thioesterase domain relocation
Yanan Sun, Guibin Tu, Xiaocan Sun, Hanchao Zhang, Haikuan Wang, Fufeng Liu, Fuping Lu, Huitu Zhang · 2026
Read Reprogramming the enduracidin NRPS assembly line via thioesterase domain relocation by Yanan Sun, Guibin Tu, Xiaocan Sun, Hanchao Zhang, Haikuan Wang, Fufeng Liu, Fuping Lu, Huitu Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13320435.txt.
Description
Yanan Sun and co-authors rewire a giant enzyme line that builds a ring shaped antibiotic in a 2026 study. The line is a chain of work stations that pass a growing chain along and snip it into a ring at the end, and its huge size makes redesign risky. A rare triple end station layout was found in this line, which hinted the end station could be moved without breaking the ring step.
The end station was shifted to new spots along the line in a set of rebuilt lines, and each still cut rings, now with set backbone lengths by design. The cutter kept its taste for the same anchor point across all lengths tested. Moving end stations may be a clean way to mint new ring drugs.
Catalog record
| CREATOR | Yanan Sun, Guibin Tu, Xiaocan Sun, Hanchao Zhang, Haikuan Wang, Fufeng Liu, Fuping Lu, Huitu Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51602 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |