Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH☆
Amy R Fumo, Simon I Dreher, Pauline Morigny, Honglei Ji, Raul Terron Exposito, Tuna F Samanci, Tushar More, Lara Ruoff, Joël J Tissink, Carmen Paredes Yubero, Ana Jimena Alfaro, Christine von Toerne, Stefanie M Hauck, Sophie HA Nusser, Zoltan Czigany, Kenneth A Dyar, Stephan Herzig, Mauricio Berriel Diaz, Anja Zeigerer, Karsten Hiller, Theresa H Wirtz, Cora Weigert, Maria Rohm · 2026
Read Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH☆ by Amy R Fumo, Simon I Dreher, Pauline Morigny, Honglei Ji, Raul Terron Exposito, Tuna F Samanci, Tushar More, Lara Ruoff, Joël J Tissink, Carmen Paredes Yubero, Ana Jimena Alfaro, Christine von Toerne, Stefanie M Hauck, Sophie HA Nusser, Zoltan Czigany, Kenneth A Dyar, Stephan Herzig, Mauricio Berriel Diaz, Anja Zeigerer, Karsten Hiller, Theresa H Wirtz, Cora Weigert, Maria Rohm (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13320412.txt.
Description
Amy R Fumo and co-authors hunt liver made signals that shrink muscle in fatty liver disease in a 2026 study joining mouse and human data. Fatty liver and muscle loss feed each other, each worsening the other odds and outlook. Liver gene reads from two mouse disease diets were crossed with muscle protein reads to spot signals the sick liver sends to muscle.
Three liver signals ran high in blood of sick mice with muscle loss and in people with advanced liver disease and muscle loss. Muscle cells dosed with liver secretions or with two of the signals shrank and burned fuel in a skewed way, and human muscle models lost function too. Muting the lead signal in mouse liver eased muscle loss, while boosting it made loss worse.
Catalog record
| CREATOR | Amy R Fumo, Simon I Dreher, Pauline Morigny, Honglei Ji, Raul Terron Exposito, Tuna F Samanci, Tushar More, Lara Ruoff, Joël J Tissink, Carmen Paredes Yubero, Ana Jimena Alfaro, Christine von Toerne, Stefanie M Hauck, Sophie HA Nusser, Zoltan Czigany, Kenneth A Dyar, Stephan Herzig, Mauricio Berriel Diaz, Anja Zeigerer, Karsten Hiller, Theresa H Wirtz, Cora Weigert, Maria Rohm |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62089 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |