Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood

Stefanos Mastrotheodoros, Winni Schalkwijk, Michelle de Groot, Sinan Gülöksüz, Stefanie A. Nelemans, Jim van Os, Bart P.F. Rutten, Wim Meeus, Marco P. Boks, Susan Branje · 2026

Read Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood by Stefanos Mastrotheodoros, Winni Schalkwijk, Michelle de Groot, Sinan Gülöksüz, Stefanie A. Nelemans, Jim van Os, Bart P.F. Rutten, Wim Meeus, Marco P. Boks, Susan Branje (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13320348.txt.

Description

Stefanos Mastrotheodoros and co-authors follow teens into young adulthood in a 2026 study of social stress, body swelling, and low mood. Stress with parents and peers in the teen years lifts later low mood risk, and lasting low grade swelling may be the bridge. Gene tag scores for a swelling marker in spit were used to test that bridge over time.

Data came from 434 teens in a Dutch study, with stress drawn from rows with parents and from peer harm, tracked to age 27. Stress showed no link to the swelling scores at age 17 or 25 and no link to low mood at 27 in the main models. One side check hinted that harsh parenting, not peer harm, may touch one swelling score in mid teens only.

Catalog record

CREATORStefanos Mastrotheodoros, Winni Schalkwijk, Michelle de Groot, Sinan Gülöksüz, Stefanie A. Nelemans, Jim van Os, Bart P.F. Rutten, Wim Meeus, Marco P. Boks, Susan Branje
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE41073
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13320348

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