Unexpected remission of Darier disease in a melanoma patient treated with trametinib and naporafenib
Karama Sboui, Nicolas Poulalhon, Luc Thomas, Stéphane Dalle · 2026
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Description
Karama Sboui and three co-authors reported an unexpected skin recovery in a 2026 case. A 64-year-old woman had Darier disease since her teens, a genetic skin disorder that causes crusty, eroded patches and repeated infections. Creams, retinoid drugs, light therapy, and lasers had all failed, and flares had sent her to hospital many times.
In 2020 she was found to have melanoma on her foot, which later spread. In January 2025 she joined a trial of two targeted cancer drugs, trametinib and naporafenib. Within three weeks her skin lesions began to clear, and by month three they were nearly gone. The gain held after one drug stopped. The authors suggest the drug pathway may restore skin integrity.
Catalog record
| CREATOR | Karama Sboui, Nicolas Poulalhon, Luc Thomas, Stéphane Dalle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |