Generalized lichen nitidus-like eruption following dupilumab initiation
Kyle Mueller, Aleodor A. Andea, Drew Kuraitis · 2026
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Description
Kyle Mueller, Aleodor A. Andea and Drew Kuraitis report, in 2026, a widespread rash resembling lichen nitidus that appeared soon after a single dose of dupilumab. Lichen nitidus is an uncommon condition of tiny grouped skin-coloured bumps, usually localised in young people. Generalised forms in adults are rarer still, and dupilumab is not a recognised trigger.
Their patient was a 71-year-old man treated for moderate to severe eczema with a standard loading dose. Two weeks later, flat-topped pale papules covered his trunk and limbs while sparing the face, palms and soles. Tissue examination showed circumscribed inflammation hugging the upper skin layer in the classic pattern for the condition, with granuloma-like features. The timing, with no other changes, led the authors to suspect the drug.
Catalog record
| CREATOR | Kyle Mueller, Aleodor A. Andea, Drew Kuraitis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |