M1 macrophage-derived exosomal miR-155-5p exacerbates aortic dissection via SMAD5-Mediated regulation of vascular smooth muscle cell phenotype
Dengwei Cao, Xinyi Li, Shaoping Zhu, Jianfeng Chen, Haoxiang Li, Jiajun Shi, Xiaoqi Xiong, Jiahui Liu, Yumou Wang, Zhe Dong, Jiangping Song, Jinping Liu · 2026
Read M1 macrophage-derived exosomal miR-155-5p exacerbates aortic dissection via SMAD5-Mediated regulation of vascular smooth muscle cell phenotype by Dengwei Cao, Xinyi Li, Shaoping Zhu, Jianfeng Chen, Haoxiang Li, Jiajun Shi, Xiaoqi Xiong, Jiahui Liu, Yumou Wang, Zhe Dong, Jiangping Song, Jinping Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13320290.txt.
Description
Dengwei Cao and co-authors trace how immune scout cells hasten a deadly aorta tear in a 2026 mouse study. A tear in the aorta wall kills fast and still lacks drug care, and wall muscle cells that switch from tight to loose form drive the tear wider. Parcels shed by angry scout cells were found to carry a gene scrap that forces that switch.
The scrap lands in wall cells, mutes a guard gene, and fires a stiffening path that flips the cells loose. Calm scout parcels were then loaded with a blocker of the scrap and given to mice prone to tears. Treated mice lived longer, tore less often, kept tighter wall cells, and showed parcels homing to the torn aorta. Engineered parcels may become drug care.
Catalog record
| CREATOR | Dengwei Cao, Xinyi Li, Shaoping Zhu, Jianfeng Chen, Haoxiang Li, Jiajun Shi, Xiaoqi Xiong, Jiahui Liu, Yumou Wang, Zhe Dong, Jiangping Song, Jinping Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83479 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |