Lysosomal aggregation of iron nanoparticles guided by multistage transformation induces potent ferroptosis
Huan Liang, Runyu Hu, Qingqing Lu, Jun Zhang, Bingyan Lu, Jie Yang · 2026
Read Lysosomal aggregation of iron nanoparticles guided by multistage transformation induces potent ferroptosis by Huan Liang, Runyu Hu, Qingqing Lu, Jun Zhang, Bingyan Lu, Jie Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13320257.txt.
Description
Huan Liang and co-authors design iron particles that swell inside cell waste sacs to kill cancer in a 2026 study. A rust driven cell death path needs iron plus acid to work well, yet tumor cell fluid is barely acid, so plain iron particles lose punch. Their shape shifting particles are built to end up in the far more acid waste sacs and grow there into lasting iron stores.
An enzyme coat helps the particles shed their shell and push deep into tumors, then sac acid swells them so they cannot be pumped back out. Trapped iron keeps making death signals, bursts the sac wall, and tips the cell into death. The death style also alerts the immune system, which adds a second attack on the tumor.
Catalog record
| CREATOR | Huan Liang, Runyu Hu, Qingqing Lu, Jun Zhang, Bingyan Lu, Jie Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59459 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |