microRNAs bidirectionally regulate FUT1 to modulate α-1,2-fucosylation and cancer-associated biology
Tigist Batu, Chu Thu, Lara K Mahal · 2026
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Description
Tigist Batu, Chu Thu and Lara K Mahal map, in 2026, how small RNA molecules regulate an enzyme that attaches fucose sugars to cell surfaces. That enzyme, FUT1, helps set blood type, shapes gut microbes and influences cancer behaviour. MicroRNAs usually switch genes down, so finding they can also switch this one up was notable.
High-throughput screening across cell lines confirmed both directions of control on the enzyme and its sugar product. Blocking natural microRNAs changed enzyme and sugar levels, proving biological weight. Binding sites for the up-regulating and down-regulating microRNAs all sat in unusual positions. The up-regulating molecules are scarce in several cancers, matching the loss of this sugar pattern seen in oesophageal cancer, melanoma and spread of disease.
Catalog record
| CREATOR | Tigist Batu, Chu Thu, Lara K Mahal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |