BMSC-derived exosomal ANTXR1 inhibits erythroid differentiation by suppressing the TLR4/MyD88/NF-κB signaling pathway
Dengyun Chen, Liping Lin, Yibo Wu, Kunbo Huang, Hanhui Zhang, Qingqing Chen · 2026
Read BMSC-derived exosomal ANTXR1 inhibits erythroid differentiation by suppressing the TLR4/MyD88/NF-κB signaling pathway by Dengyun Chen, Liping Lin, Yibo Wu, Kunbo Huang, Hanhui Zhang, Qingqing Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13319825.txt.
Description
Dengyun Chen and five co-authors studied a brake on red blood cell formation in a 2026 paper. Aplastic anemia is a marrow failure where blood production falters. Stem cells from marrow release tiny vesicles that carry messages between cells. The team asked what one cargo protein, called ANTXR1, does to the making of red cells, using mouse stem cells and human blood-forming cells.
Vesicles rich in the protein slowed red cell development: key markers fell, and hemoglobin production dropped. Vesicles lacking it did the opposite and switched on an inflammatory signaling chain. Blocking that chain blunted the effect, and the protein was shown to bind its first link. The findings name a vesicle route that may worsen anemia.
Catalog record
| CREATOR | Dengyun Chen, Liping Lin, Yibo Wu, Kunbo Huang, Hanhui Zhang, Qingqing Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |