Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysis
Elin Wik, Amelia D. Dahlén, Ulrika Julku, Mengfei Xiong, Wojciech Michno, Stina Syvänen, Dag Sehlin · 2026
Read Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysis by Elin Wik, Amelia D. Dahlén, Ulrika Julku, Mengfei Xiong, Wojciech Michno, Stina Syvänen, Dag Sehlin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13319731.txt.
Description
Elin Wik and co-authors trace a brain seeking antibody drug in mice in a 2026 study tied to Alzheimer care. The drug was built to latch onto clumps of a sticky brain protein, first in loose form and later in hard plaques. How fast it moves through brain fluid and shifts between those pools in the first day was not yet mapped.
Fine tubes drew brain fluid from awake mice across 24 hours after one dose, and brain tissue was split by clump type after death. The drug cleared from fluid fast and shifted over time from loose clumps toward plaque bound pools. Loose clump levels fell within 12 hours of dosing. Hard plaque clearing will need longer care, the team notes.
Catalog record
| CREATOR | Elin Wik, Amelia D. Dahlén, Ulrika Julku, Mengfei Xiong, Wojciech Michno, Stina Syvänen, Dag Sehlin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42769 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |