Potential Anticancer Effects of Limonene Associated with Reactive Oxygen Species Generation, Apoptosis Induction, and NF-κB Modulation in Papillary Renal Cell Carcinoma: A Preliminary Study
Mahshad Ghanbari, Roham Deyhimfar, Fatemeh Khatami, Idris Haghani, Iman Menbari Oskouie, Mahdi Khoshchehreh, Seyed Mohammad Kazem Aghamir · 2026
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Description
Mahshad Ghanbari and co-authors test, in 2026, whether limonene, a fragrant compound from citrus peel, can fight papillary kidney cancer cells in the laboratory. Kidney cancers often recur or progress, creating demand for safer treatments, and limonene has shown anticancer effects in prostate and bladder models.
Treated cancer cells lost viability in a dose and time dependent way, while normal kidney and skin cells were less affected. Migration, colony growth and three-dimensional spheroid growth all fell. The compound raised reactive oxygen species and increased cell suicide, called apoptosis, without changing the cell cycle. Gene activity shifted away from growth and invasion programmes, and a key inflammatory switch was reduced at protein level. The authors present the work as preliminary support for further study.
Catalog record
| CREATOR | Mahshad Ghanbari, Roham Deyhimfar, Fatemeh Khatami, Idris Haghani, Iman Menbari Oskouie, Mahdi Khoshchehreh, Seyed Mohammad Kazem Aghamir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |