Exploring drug repurposing for monkeypox virus: A structural and computational approach
Somia Gul, Faiza Akhtar, Iqra Rehman, Muhammad Shah, Umer Rashid, Abdur Rauf · 2026
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Description
Somia Gul and co-authors test old drugs for new use against monkeypox in a 2026 computer based study. The virus spreads from animals to people and belongs to a family close to the smallpox virus. Drugs cleared for smallpox may thus fit its proteins too, and reusing known drugs could speed up the search for care.
A cleared smallpox drug served as the yardstick while 38 cleared drugs from four drug classes were docked in software against key virus proteins. Several drugs bound more strongly than the yardstick in these tests. Motion checks on the best pairs held steady over time, which supports them as leads. Lab and animal proof must come before any clinical use.
Catalog record
| CREATOR | Somia Gul, Faiza Akhtar, Iqra Rehman, Muhammad Shah, Umer Rashid, Abdur Rauf |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43036 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |