The entropic view of aging: from thermodynamics to biology
Zeming Wu, Shuai Ma, Si Wang, Moshi Song, Weiqi Zhang, Jing Qu, Juan Carlos Izpisua Belmonte, Guang-Hui Liu · 2026
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Description
Zeming Wu and co-authors propose, in 2026, viewing ageing through entropy, the physical measure of disorder. Evidence increasingly suggests ageing is not just accumulated damage but a system-wide drift toward disorder at every scale, from molecules to organs. The authors build a three-stage model of the lifespan.
Development builds order, adulthood holds order steady, and later life becomes dominated by disorder. Known hallmarks of ageing are reframed as connected nodes in one entropy-centred network. To make the idea measurable, the authors sketch a multiscale index that would combine disorder readings across biological levels. They present it as a proof of concept. If entropy reduction proves to be a shared mechanism behind effective interventions, the framework could guide new biomarkers and rejuvenation strategies.
Catalog record
| CREATOR | Zeming Wu, Shuai Ma, Si Wang, Moshi Song, Weiqi Zhang, Jing Qu, Juan Carlos Izpisua Belmonte, Guang-Hui Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |