Uncertainty analysis of single-time-point organ dosimetry compared with the multi-time-point method in radioimmunotherapy
Amit Nautiyal, Gemma Lewis, Jonathan I. Gear, Kim Orchard, Matthew J. Guy, Sofia Michopoulou · 2026
Read Uncertainty analysis of single-time-point organ dosimetry compared with the multi-time-point method in radioimmunotherapy by Amit Nautiyal, Gemma Lewis, Jonathan I. Gear, Kim Orchard, Matthew J. Guy, Sofia Michopoulou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13319317.txt.
Description
Amit Nautiyal and five co-authors measure how much error creeps into radiation dose estimates when clinics take the shortcut of a single scan. In radioimmunotherapy, patients receive a radioactive drug, and planners must estimate the dose each organ absorbs. The full method images the patient at several time points, while the shortcut uses one.
The study covers 28 patients with blood cancers, treated first with a tracer dose and then with the therapy itself. Dose estimates for bone marrow matched closely between the two methods. For the liver, the average dose was similar, but the uncertainty was far larger with the single-scan method, about fifty percent against six percent. Uncertainty also grew with the delay before scanning. The authors urge clinics to report uncertainty whenever the shortcut is used.
Catalog record
| CREATOR | Amit Nautiyal, Gemma Lewis, Jonathan I. Gear, Kim Orchard, Matthew J. Guy, Sofia Michopoulou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |