High interobserver reliability of neutrophil phenotyping based on visual determination of CD16/CD62L expression patterns
Christian Thomas Hübner, Emma de Fraiture, Frederique van Eerten, Felix Karl-Ludwig Klingebiel, Nathalie Piaz, Hans-Christoph Pape, Leo Koenderman, Michel Paul Johan Teuben, Falco Hietbrink · 2026
Read High interobserver reliability of neutrophil phenotyping based on visual determination of CD16/CD62L expression patterns by Christian Thomas Hübner, Emma de Fraiture, Frederique van Eerten, Felix Karl-Ludwig Klingebiel, Nathalie Piaz, Hans-Christoph Pape, Leo Koenderman, Michel Paul Johan Teuben, Falco Hietbrink (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13319249.txt.
Description
Christian Thomas Hübner and eight co-authors present a study from twenty twenty-six on how well observers agree when they grade white blood cells by eye. After trauma, two surface marks on neutrophils sort them in seven classes that track inflammation. The bedside method reads dot plots by pattern. Forty raters of mixed training graded fifty plots with a standard guide.
Full seven class agreement was fair, with mix ups at the mild end. Bad inflammation plots were near never read as mild. Lumped in two classes, mild versus high, agreement rose to near perfect. The team backs the two class read for bedside use. The full scale can stay for research.
Catalog record
| CREATOR | Christian Thomas Hübner, Emma de Fraiture, Frederique van Eerten, Felix Karl-Ludwig Klingebiel, Nathalie Piaz, Hans-Christoph Pape, Leo Koenderman, Michel Paul Johan Teuben, Falco Hietbrink |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |