Troxerutin suppresses the stemness of hepatocellular carcinoma via the Syk/FOXO3 feedback loop
Shan Liu, Yuan Lin, Huan Xia, Hanhan Li, Yan Dou, Jiamin Luo, Tiantian Yang, Qi Zeng, Wei Guo, Hanrui Chen · 2026
Read Troxerutin suppresses the stemness of hepatocellular carcinoma via the Syk/FOXO3 feedback loop by Shan Liu, Yuan Lin, Huan Xia, Hanhan Li, Yan Dou, Jiamin Luo, Tiantian Yang, Qi Zeng, Wei Guo, Hanrui Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13319154.txt.
Description
Shan Liu and co-authors test a plant based compound in a 2026 liver cancer study. This cancer returns and spreads at high rates, which keeps it among the deadliest cancers. New drugs and new angles of attack are needed to improve patient outcomes.
The compound, called troxerutin, was tested on cancer cells for growth, death, movement, and stem like traits. Stem like cells can restart a tumor, so curbing them matters. Gene and protein tests traced the effect to a loop between two cell signals, named Syk and FOXO3. The work maps a path by which the compound may weaken the tumor's core cells.
Catalog record
| CREATOR | Shan Liu, Yuan Lin, Huan Xia, Hanhan Li, Yan Dou, Jiamin Luo, Tiantian Yang, Qi Zeng, Wei Guo, Hanrui Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |