Twin growth discordance trajectories and fetal growth velocity for predicting adverse neonatal outcomes: a multicenter cohort study
Minhuan Lin, Xuewen Huang, Yuheng Zhou, Shuting Xia, Dongmei Duan, Yingnan Ye, Yiqing Chen, Linhuan Huang, Jiying Wen, Yanmin Luo · 2026
Read Twin growth discordance trajectories and fetal growth velocity for predicting adverse neonatal outcomes: a multicenter cohort study by Minhuan Lin, Xuewen Huang, Yuheng Zhou, Shuting Xia, Dongmei Duan, Yingnan Ye, Yiqing Chen, Linhuan Huang, Jiying Wen, Yanmin Luo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13319096.txt.
Description
Minhuan Lin and a large team present a 2026 multicentre cohort study of uneven growth between twins and newborn outcomes. The study followed 1,930 twin pregnancies with at least three ultrasound scans. One centre built the model and another validated it. Growth-gap patterns over time were combined with the smaller twin's growth speed.
Four gap trajectories emerged from the modelling. A stable low gap covered 84.1 percent of pregnancies in their data. Two high-gap patterns, one easing and one rising, each roughly tripled the odds of bad newborn outcomes. Adding the smaller twin's growth velocity improved prediction beyond trajectory alone. The combined model reached an AUC of 0.696 in development and 0.733 in external validation. Growth speed of the smaller twin was the single strongest predictor.
Catalog record
| CREATOR | Minhuan Lin, Xuewen Huang, Yuheng Zhou, Shuting Xia, Dongmei Duan, Yingnan Ye, Yiqing Chen, Linhuan Huang, Jiying Wen, Yanmin Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34702 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |