A mitochondrial regulatory network of ferroptosis defense in HPV-positive cervical cancer: therapeutic implications of the mitoSTAT3-DHODH axis
Shi Feng, Yang Huang, Zhi Li, Zhanxu He, Yuhong Gao · 2026
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Description
Shi Feng and colleagues propose, in a 2026 review, a mitochondria-centred defence network that helps HPV-positive cervical cancer resist ferroptosis, an iron-driven cell death. Standard chemoradiation often fails against these tumours. The authors centre their framework on mitochondrial STAT3 and the enzyme DHODH. Both sit inside the cell's power plant.
Viral proteins E6 and E7 keep tumour cells under constant growth and oxidative pressure. That pressure raises dependence on mitochondrial control systems. Mitochondrial STAT3 may keep energy production efficient and limit electron leaks. DHODH may supply a protective antioxidant inside the membrane. Together they could hold back membrane damage and cell death. The review maps drug strategies against this axis, including combinations and patient selection markers.
Catalog record
| CREATOR | Shi Feng, Yang Huang, Zhi Li, Zhanxu He, Yuhong Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89498 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |