Association between TNF-α (−308G > A) promoter polymorphism and HHV-6 DNA detection in a community-based Thai cohort
Sureewan Bumrungthai, Sutida Pongpukdeesakul, Tipaya Ekalaksananan, Sureewan Duangjit, Chamsai Pientong, Nuchsupha Sunthamala · 2026
Read Association between TNF-α (−308G > A) promoter polymorphism and HHV-6 DNA detection in a community-based Thai cohort by Sureewan Bumrungthai, Sutida Pongpukdeesakul, Tipaya Ekalaksananan, Sureewan Duangjit, Chamsai Pientong, Nuchsupha Sunthamala (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13318981.txt.
Description
Sureewan Bumrungthai and colleagues present a 2026 community study in Thailand linking a gene variant to detection of human herpesvirus 6. The virus infects most people in childhood and then stays latent. A promoter variant in the TNF-α gene may tilt the host-virus balance. The sample covered 852 people aged 3 to 90 in Phayao Province.
Viral DNA was found in 12.8 percent of participants overall. Detection rose steadily with age. Carriers of the −308G>A variant had clearly higher odds of a positive test. The adjusted odds ratio was 3.21 in their model. Lower education also linked to detection, while psychological measures did not. The authors stress that long-term studies must test whether the link is causal.
Catalog record
| CREATOR | Sureewan Bumrungthai, Sutida Pongpukdeesakul, Tipaya Ekalaksananan, Sureewan Duangjit, Chamsai Pientong, Nuchsupha Sunthamala |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48893 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |