An evolutionary genomic perspective on preterm birth, genome editing, and pregnancy in the human species
Akua A. Obeng, Monica Uddin, Chengqi Wang, Derek E. Wildman · 2026
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Description
Akua A. Obeng and colleagues offer a 2026 evolutionary genomics perspective on preterm birth and pregnancy. Birth timing varies widely across species, shaped by long change over time. Preterm birth can follow infection, anatomy, injury, age, or multiple pregnancy. Each cause touches partly separate gene networks.
Starting from about 1,500 pregnancy-related genes, the authors hunted for recent shifts. Many relevant genes show lineage- or group-specific shifts. They include progesterone signalling, innate immunity, and placenta regulation genes. DNA sites are flagged where CRISPR disruption would likely alter labour or birth. Examples sit in hormone receptors and placenta-only genes such as LGALS13. The framework separates conserved, risky targets from flexible ones for safer future studies.
Catalog record
| CREATOR | Akua A. Obeng, Monica Uddin, Chengqi Wang, Derek E. Wildman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89233 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |