Decoding signaling crosstalk in pulpitis: pathogenesis and precision therapeutics
Zhaohui Jia, Zongzong Sun, Hairui Zhou · 2026
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Description
Zhaohui Jia, Zongzong Sun, and Hairui Zhou review, in 2026, the signalling cross-talk inside irreversible pulpitis, the painful inflammation of tooth pulp. The pulp sits in a rigid dentine chamber with little room to swell. Inflammation there easily tips into tissue death. Several molecular pathways fight or cooperate in that space.
Inflammatory routes such as TLR/NF-κB and MAPK drive the damaging cascade. Low oxygen raises HIF-1α and rewires metabolism, while the NLRP3 inflammasome adds cell death. Repair pathways, Wnt and TGF-β, try to rebuild dentine but are often suppressed. The authors assess targeted plant chemicals, gene regulators, and resolving mediators such as Resolvin E1. Smart materials that respond to pulp conditions also feature in their plan for precise vital pulp therapy.
Catalog record
| CREATOR | Zhaohui Jia, Zongzong Sun, Hairui Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50815 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |