Development and characterization of a monoclonal antibody against Pseudorabies virus glycoprotein B and its application in tracking viral infection
Hai-Ming Wang, Yue Sun, Yu Wang, Ping-Yu Huang, Peng Liu, Yanhe Zhang, Yan-Dong Tang · 2026
Read Development and characterization of a monoclonal antibody against Pseudorabies virus glycoprotein B and its application in tracking viral infection by Hai-Ming Wang, Yue Sun, Yu Wang, Ping-Yu Huang, Peng Liu, Yanhe Zhang, Yan-Dong Tang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13318859.txt.
Description
Hai-Ming Wang and colleagues report a 2026 laboratory study creating a monoclonal antibody against pseudorabies virus. The swine herpesvirus causes heavy losses in the pig industry. Its glycoprotein B is a conserved surface protein needed for viral entry and cell fusion. That makes it a prime target for detection tools.
The team produced the outer part of glycoprotein B from the HeN1 strain in CHO cells. Mice were immunised, and fused cells yielded an antibody named 1G4. Tests showed strong specificity and reactivity. The antibody recognised multiple virus strains broadly. Labelled with a fluorescent tag and paired with another antibody, it tracked virus entry into HeLa cells under the microscope. The authors offer it as a reagent for mechanism research and immune detection.
Catalog record
| CREATOR | Hai-Ming Wang, Yue Sun, Yu Wang, Ping-Yu Huang, Peng Liu, Yanhe Zhang, Yan-Dong Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27232 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |