Effect of antihypertensive medication reduction on short-term blood pressure control in older adults: calibration of OPTiMISE trial results to real-world primary care data
Antoine Christiaens, Ariel Wang, David A McAllister, Richard J McManus, James P Sheppard · 2026
Read Effect of antihypertensive medication reduction on short-term blood pressure control in older adults: calibration of OPTiMISE trial results to real-world primary care data by Antoine Christiaens, Ariel Wang, David A McAllister, Richard J McManus, James P Sheppard (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13318848.txt.
Description
Antoine Christiaens and colleagues test, in 2026, whether a trial result on reducing blood pressure medicines in very old adults holds in routine English primary care. The OPTiMISE trial found that stopping one such drug did not worsen short-term control in people aged 80 and over. Trial participants, however, are usually fitter than typical patients.
The team rebuilt a target population from records of practices in England, covering nearly eight hundred thousand eligible adults. This real-world group was frailer and carried more illness than trial participants. Statistical weighting aligned the groups on likely trial entry. After calibration, reducing medication was not linked to higher risk of hospital stay or death, matching the trial's long-term findings. The authors judge the result transferable, with somewhat wider uncertainty.
Catalog record
| CREATOR | Antoine Christiaens, Ariel Wang, David A McAllister, Richard J McManus, James P Sheppard |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |